Treatment-Resistant Depression
If antidepressants haven’t been enough, there’s a clinical term for that and more specific options because of it.
Have you been trying to treat depression for a while?
Treatment-resistant depression is a clinical term for depression that hasn’t adequately responded to at least two different antidepressants, tried at sufficient doses and for sufficient time.
If that’s where you are, you probably don’t need a definition. You may have started to wonder whether treatment is actually going to help you. That discouragement is understandable.
We want you to know that treatment-resistant depression is a more specific clinical picture, and that picture opens access to approaches that weren’t appropriate earlier in the process.
At Origin Mental Wellness, we help uncover why your depression isn’t responding to treatment.
Sometimes the issue is diagnostic: depression presenting alongside another condition that hasn’t been identified or treated.
Sometimes it’s about medication fit: the specific drugs or doses tried haven’t been the right match for your biology.
And sometimes there are physiological factors contributing to the depression that haven’t been evaluated: metabolic disruption, chronic inflammation, hormonal imbalance, nutrient deficiencies. These aren’t psychiatric conditions on their own, but they can meaningfully undermine how the brain responds to psychiatric treatment.
Our evaluation explores these possibilities.
We tailor treatment for your situation.
Mental health treatment may include:
Spravato® (Esketamine) Treatment
Spravato® is FDA-approved specifically for treatment-resistant depression. It acts on a different neurological pathway than traditional antidepressants and can produce meaningful relief on a different timeline. Administered in-office under clinical supervision at our downtown Columbus location on 150 E Main St.
Brain Energy & Metabolism Assessment
A deeper biological assessment examining the physiological factors that may be sustaining your depression, including metabolism, inflammation, hormones, nutrient status, sleep, and nervous system function.
GeneSight® Testing
Genetic analysis that helps clarify which medications are most likely to be effective and well-tolerated for your specific biology. Particularly useful if you have a history of multiple medication trials.
Careful Medication Review
A thorough re-evaluation of your medication history: what you’ve tried, how you responded, and what the clinical picture suggests about next steps.